The first season of the television comedy series Mike & Molly aired between September 20, 2010 and May 16, 2011, on CBS in the United States. The season was produced by Chuck Lorre Productions and Warner Bros. Television, with series creator Mark Roberts serving as executive producer along with Chuck Lorre, James Burrows and Don Foster. The series focuses on the title characters Mike Biggs and Molly Flynn, a couple who meet at an Overeaters Anonymous meeting in Chicago, Illinois. After Molly, a primary-school teacher, invites police officer Mike to give a talk to her class, they begin dating. Molly lives at home with her mother Joyce, and sister Victoria. Joyce is in an on-off relationship with widower Vince Moranto, who is often seen at the house. Mike lives alone in an apartment but is regularly kept company by his best friend and partner in the police force Carl McMillan. Other prominent characters in the series include Carl's grandmother Rosetta; Mike's mother Peggy and cafe worker Samuel. Season one of Mike & Molly consisted of 24 episodes and aired Mondays in the United States at 9.30 p.m. until April 11, 2011, with the final three episodes airing at 9.00 p.m.

The second season of the television comedy series Mike & Molly began airing on September 26, 2011 on CBS in the United States. The season is produced by Chuck Lorre Productions and Warner Bros. Television, with series creator Mark Roberts serving as executive producer along with Chuck Lorre, James Burrows and Don Foster. The series focuses on the title characters Mike Biggs and Molly Flynn, a couple who meet at an Overeaters Anonymous meeting in Chicago, Illinois. After Molly, a primary-school teacher, invites police officer Mike to give a talk to her class, they begin dating. Molly lives at home with her mother Joyce, and sister Victoria. Joyce is in an on-off relationship with widower Vince Moranto, who is often seen at the house. Mike lives alone in an apartment but is regularly kept company by his best friend and partner in the police force Carl McMillan. Other prominent characters in the series include Carl's grandmother Rosetta; Mike's mother Peggy and cafe worker Samuel. Holly Robinson Peete has a recurring guest role in Season 2 as Carl's love interest. Season two of Mike & Molly broadcasts on Mondays in the United States at 9:30 P.M.

The end of Mike and Molly's romantic honeymoon in Paris marks the beginning of wedded bliss. The newlyweds can't wait to start married life.

Molly decides to leave her teaching career to become a writer. When Molly decides to start a career as a crime novelist, she goes on a ride-along with Mike to research her first book.

Molly’s literary dreams take flight—but can her marriage keep up? As Molly celebrates a major book deal, the couple faces new challenges, from writer’s block to unexpected temptations. With family antics and heartfelt moments, Season 5 delivers laughs and love in equal measure.

Love, Laughter & One Last Ride – In their final chapter, Mike and Molly chase their dream of starting a family. From adoption hurdles to heartfelt goodbyes, Season 6 delivers big laughs and bigger love as the series wraps with a warm and witty farewell.