Priest Genjo Sanzo and companions Cho Hakkai, Sha Gojyo, and Son Goku maintain their westward journey to stop the resurrection of the demon Gyoumao. As the reputation of the Sanzo Ikkou precedes them, they continue to fight demon assassins at every turn, but they must also deal with increasing tensions within their group in order to defeat a powerful enemy.

The Sanzo Ikkou continues its westward journey, on a mission to prevent a demonic resurrection. As Genjo Sanzo, Cho Hakkai, Sha Gojyo, and Son Goku fight their way to their goal, their path is fraught with internal strife. When they encounter a formidable pair of adversaries from the west, the cohesion of the group -- and the fate of the mission -- may be at stake.

Humans and yokai, science and magic... all exist side-by-side on a peaceful continent free of all order and regulation, widely known as "Shangri-La." The balance there was shattered when the Minus Wave caused all the yokai on the continent to rampage, an event known as the "Calamity." Continuing their journey west to stop Gyumaoh's resurrection experiments, the root of all the evil on the continent, the Three Aspects are finally drawing closer to India. But the closer they get, the more pronounced the influence of the Calamity becomes, and the more intense their battles become.

Once, the land of Togenkyo was a peaceful land, where humans and yokai lived together. Then, however, men appeared who tried to revive Gyumaoh, the Great Yokai who was slain by the war god Nataku Taishi and buried in Houtou Castle 500 years ago, by using a forbidden combination of chemistry and magic The negative energy waves this created spread across Togenkyo, causing the yokai to go insane and attack humanity. To save the land, Kanzeon bosatsu orders Son Goku, Genjyo Sazno, Sha Gojyo, and Cho Hakkai to go west. The four set out on a journey to stop the experiment to revive Gyumaoh. On the way, they meet Hazel Grouse, who employs strange magic that uses yokai souls to revive the dead, and his follower Gato. The two of them join the party. And Ukoku Sanzo, a man they have a long history with, approaches in the shadows... Unforgettable characters, intense personal drama, and awesome action in a story about the bonds between four men!