Shinichi Chiaki is a first class musician whose dream is to play among the elites in Europe. Coming from a distinguished family, he is an infamous perfectionist—not only is he highly critical of himself, but of others as well. The only thing stopping Shinichi from leaving for Europe is his fear of flying. As a result, he's grounded in Japan. During his fourth year at Japan's top music university, Shinichi happens to meet Megumi Noda or, as she refers to herself, Nodame. On the surface, she seems to be an unkempt girl with no direction in life. However, when Shinichi hears Nodame play the piano for the first time, he is in awe of the kind of music she creates. Nevertheless, Shinichi is dismayed to discover that Nodame is his neighbor, and worse, she ends up falling head over heels in love with him.

Shinichi Chiaki conquers his fear of flying, and Megumi "Nodame" Noda's exceptional performance at a piano competition earns her an invitation to study at the prestigious Conservatoire de Paris. The pair go to Paris together to take the next step in their careers: Chiaki as a new rising conductor under the wing of the great maestro Franz von Stresemann, and Nodame as a pupil of the esteemed piano professor Charles Auclair. But, of course, the music world is much bigger than the two of them could have ever imagined. Chiaki and Nodame, alongside old friends and new rivals, must fight and persevere to reach the dazzling musical heights that await them while never losing sight of what matters most.

Shinichi Chiaki is quickly making a name for himself as the principal conductor of the revitalized Roux-Marlet Orchestra, and Megumi "Nodame" Noda has made leaps and bounds as a pianist at the Conservatoire de Paris. However, tensions mount between the two as Nodame feels left behind by Chiaki's growing success and his close friendship with legendary piano prodigy Rui Son. Disregarding her teacher Professor Charles Auclair's advice, Nodame enters another piano competition in an attempt to jumpstart her own performance career. Meanwhile, those around Chiaki and Nodame are at their own crossroads. As Chiaki, Nodame, and their friends continue on their respective journeys, they must not only strive to stay true to themselves, but also remember where it all started.