Jonathan Joestar's antagonistic relationship with his adopted brother Dio begins a truly bizarre lineage, which is continued by his grandson Joseph.

Joseph Joestar's grandson Jotaro Kujo has a strange new superpower, which turns out to be connected to the reemergence of old foe Dio Brando.

The lineage continues as Joseph Joestar's grandson Jotaro arrives in Morioh to warn his relative Josuke Higashikata of dangerous new Stand users.

In Naples, Italy, the suspected son of Joestar family arch nemesis Dio dreams of becoming a Gang Star so he can bring down the local mafia from within.

The legacy of the Joestar family continues with Jolyne as she and her companions take on new Stand users behind the bars of Green Dolphin Street Prison.

In 1890s USA, paraplegic Johnny Joestar forms an alliance with mysterious outlaw Gyro Zeppeli and the two participate together in the first-ever cross-continental horse race across North America.