Four year ten students-Jake, Felix, Andy and Sam-are grouped together during a school orienteering excursion at the Bremin Ranges National Park and get lost. After getting caught in an unexpected storm, the boys spend the night in the forest. When they return home the next morning, the boys get chased by a furious tornado and discover that some strange things have happened; Felix's disabled brother Oscar can walk, Andy's sister Viv owns his room, and Jake cannot get into his house.

The Nowhere Boys have found their way home, but Felix, Jake, Sam and Andy soon discover the adventure doesn't stop just because they're back. As they experiment with their new and unpredictable powers over earth, wind, fire and water, the boys realise they aren't the only ones who crossed back to this universe.

In the final series, the Nowhere Boys are back more powerful than ever and with an unlikely new member. But the new-year brings their most dangerous threat yet – an enemy capable of destroying the entire multiverse.