Following the sudden loss of matriarch Roseanne, the Conner family navigates life in Lanford with resilience and humor. Dan, Jackie, Darlene, Becky, and D.J. face new challenges, from financial struggles to parenting woes, all while leaning on each other for support.

The Conners continue to adapt to life’s ups and downs. Darlene pursues a new relationship with her boss, Ben, while Becky confronts unexpected news about her pregnancy. The family grapples with evolving dynamics, work challenges, and the complexities of modern life.

Set against the backdrop of the COVID-19 pandemic, the Conners face unprecedented challenges. With the Lunch Box limited to takeout, Becky and Darlene seek employment at Wellman Plastics. The season delves into themes of health, economic hardship, and the enduring strength of family bonds.

Love is in the air as multiple family members plan a shared wedding event. Amid preparations, the Conners confront personal growth, sobriety journeys, and the complexities of blended families, all while maintaining their signature humor and heart.

New beginnings and unexpected challenges arise. Darlene and Ben, along with Jackie and Neville, embark on joint honeymoons, leading to comedic mishaps. The family navigates evolving relationships, career changes, and the ever-present trials of daily life in Lanford.

As the Conners approach significant life milestones, they reflect on past decisions and future aspirations. Darlene supports Mark’s college ambitions, Becky balances motherhood with personal growth, and Dan contemplates retirement, all while the family remains united through life’s unpredictabilities.

In the final season, the Conners confront lingering grief and seek justice for past losses. Jackie considers rejoining the Lanford PD, Mark faces moral dilemmas in his new job, and the family collectively sues a pharmaceutical company over Roseanne’s death. The series concludes with heartfelt moments, emphasizing resilience, love, and the enduring spirit of the Conner family.