Michael Cera

E1

Zach puts Michael Cera, the Superbad and Juno star in the hot seat for this special Comedy Death-Ray interview.

Jimmy Kimmel

E2

Zach interviews talk show host Jimmy Kimmel.

Jon Hamm

E3

Zach interviews Jon Hamm of AMC's Mad Men.

Natalie Portman

E4

Zach interviews Natalie Portman and her dog, Whiz.

Bradley Cooper

E5

Zach chats with Bradley Cooper, star of "The Hangover."

Charlize Theron

E6

Zach has a chat with Charlize Theron, Academy Award winner and star of The Road.

Conan O'Brien & Andy Richter

E7

Zach sits down with the host of the Tonight Show, Conan O'Brien, and his announcer, Andy Richter.

Ben Stiller

E8

Zach sits down with Ben Stiller, star of the 'Meet the Fockers' series as well as the new movie, Greenberg.

Steve Carell

E9

Zach sits down with Steve Carell from "The Office" and they quite possibly discuss "Dinner for Schmucks".

Sean Penn

E10

Sean Penn sits down with Zach's twin brother, Seth Galifianakis.

Bruce Willis

E11

Zach sits down with Bruce Willis; one of the stars of the new movie Red, to talk about the 80s and some of the prestigious awards he has been awarded.

Jennifer Aniston & Tila Tequila

E12

Zach sits down with Tila Tequila who may become his new best friend and also welcomes another guest on the show who some people may recognize (Jennifer Aniston).

Will Ferrell

E13

Zach sits down with Will Ferrell, the star of Everything Must Go, Anchorman and Old School, to talk about lunch, dance teams and to show a never before seen clip from his movie.

Oscar Buzz Edition (1)

E14

Zach Galifianakis sits down with Jennifer Lawrence, Anne Hathaway, Christoph Waltz, Naomi Watts & Amy Adams who are getting all the buzz during this Oscar season.

Oscar Buzz Edition (2)

E15

Zach Galifianakis sits down with Bradley Cooper, Jessica Chastain, Sally Field and another special guest from Lincoln.

James Franco

E16

Zach Galifianakis sits down with James Franco to have a normal, everyday, run of the mill interview.

Justin Bieber

E17

Zach Galifianakis sits down with Justin Bieber for an interview no one will ever forget.

President Barack Obama

E18

President Barack Obama sits down with Zach Galifianakis for his most memorable interview yet.

Brad Pitt

E19

Brad Pitt sits down with Zach Galifianakis for his second most memorable interview yet.

Hillary Clinton

E20

Hillary Clinton sits down with Zach Galifianakis for her most memorable interview yet.

Jerry Seinfeld & Cardi B

E21

Jerry Seinfeld and Cardi B sit down with Zach Galifianakis for an interview without coffee, cars, or money moves.