Luke Wilson, Julie Chen, Lee Brice
E1
Kristen Wiig, Sen. Elizabeth Warren, The New Pornographers
E2
Steve Buscemi, Indy Car Season Champ, Alt-J
E3
Tina Fey, Moody McCarthy, Kevin Drew
E4
Bill Maher, Henrik Lundqvist, Spoon
E5
Michael Strahan, Richard Branson, Interpol
E6
Dr. Phil, Katharine McPhee, Death from Above 1979, Ray Benson
E7
Jason Bateman, Billy Eichner, Ryan Adams
E8
Mindy Kaling, Jake Johannsen, Maddie & Tae
E9
Mark Harmon, "Jungle" Jack Hanna
E10
Denzel Washington, Lenny Kravitz
E11
Kelly Ripa, Jim Gaffigan, Paloma Faith
E12
Jerry Seinfeld, Michael Jackson ONE
E13
Ted Danson, Andrew Norelli
E14
Neil Patrick Harris, Jamie Oliver, Aretha Franklin
E15
John Oliver, Maggie Q, Bleachers
E16
Bill O'Reilly, Cristin Milioti
E17
Johnny Galecki, Andre Benjamin, Delta Spirit
E18
Mariska Hargitay, Simon Amstell, Kandace Springs
E19
Aziz Ansari, Tom Dreesen
E20
Robert Downey Jr., Sarah Paulson, Lizzo
E21
Anderson Cooper, Gina Rodriguez, Hatsune Miku
E22
Robert Duvall, Elle Fanning, Rival Sons
E23
Chelsea Handler; Keegan-Michael Key and Jordan Peele; Angaleena Presley
E24
TV host Chelsea Handler; comics Keegan-Michael Key and Jordan Peele; Angaleena Presley performs.
Russell Brand, Dave Grohl, Foo Fighters
E25
Michael Keaton, Foo Fighters
E26
Bill Murray, Foo Fighters
E27
Tom Selleck, Jenny Slate, Foo Fighters
E28
Jessica Chastain, Lenny Marcus, Foo Fighters
E29
Amy Poehler, Sen. Jeff Flake, Sen. Martin Heinrich, Mastodon, Jerry Lee Lewis
E30
Taylor Swift, Tom Mison
E31
Jim Carrey, David Tennant
E32
Brian Williams, Perfume Genius
E33
Keith Olbermann, Brian Regan, Run the Jewels
E34
Martin Short, Father John Misty
E35
Jennifer Lopez, Rob Riggle, Kimbra
E36
Whoopi Goldberg, Jimmy Page, Mapei
E37
Amy Schumer, Jeff Caldwell
E38
Katie Holmes, Alex Zanardi
E39
Steve Carell, Martha Stewart, OK Go
E40
Jennifer Lawrence, Boris Johnson
E41
Jon Stewart, Shawn Mendes
E42
Kristin Chenoweth; Chris Young
E43
Actress Kristin Chenoweth; Chris Young performs.
Jason Sudeikis, Allison Janney, Damien Rice
E44
Stupid Pet Tricks, Charlie Day, Hiss Golden Messenger
E45
Regis Philbin, Hundred Waters
E46
Edward Norton, Jessye Norman
E47
Norman Lear, TV on the Radio
E48
Seth Rogen, Amy Sedaris
E49
Emily Blunt, Adam Resnick, Wu-Tang Clan
E50
Jake Gyllenhaal, Dr. John P. Holdren, Nico & Vinz
E51
Joaquin Phoenix, Cristela Alonzo, Al Green
E52
Ben Stiller, Olivia Munn, LaLa Brooks
E53
Meryl Streep, Rebel Wilson, J. Cole
E54
Chris Rock, Sting
E55
Jamie Foxx, Robert Klein, Dan Penn
E56
Emma Stone Top, Marcus Mariota, Bob Seger
E57
New Holiday Toys, Anna Kendrick, Charli XCX
E58
Tom Brokaw, Will Nelson & Billy Joe Shaver
E59
Rosie O’Donnel,l Jeff Altman
E60
Jay Thomas, Josh Brolin, Darlene Love
E61
The final Christmas episode. Jay Thomas drops by to once again tell "The best talk show story, ever", then he and David try to knock the meatball off the Christmas tree in the Late Show Quarterback Challenge. An interview with Josh Brolin. The show wraps up with Darlene Love's last Late Show performance of Christmas (Baby Please Come Home).
Kathy Griffin, David Oyelowo, Lera Lynn
E62
Ethan Hawke, Allison Williams, Parquet Courts
E63
Julianne Moore, Catfish & the Bottlemen
E64
Donald Trump, Chelsea Peretti, Foxygen
E65
Michael Somerville, Nicole Atkins
E66
Gordon Ramsay, Adam Devine, St. Paul and the Broken Bones
E67
Anderson Cooper, Shovels & Rope
E68
Amanda Peet, Ryn Weaver
E69
Larry David, Dan Patrick, Sleater-Kinney
E70
Urban Meyer, Johnny Beehner, Ella Henderson
E71
Louis CK, Nicolle Wallace, the Lone Bellow
E72
Andrew Luck, Oscar Isaac, Drenge
E73
Viola Davis, Ben Schwartz, Marty Stuart
E74
John Oliver, Mayim Bialik, Death Cab for Cutie
E75
Aziz Ansari, Brian Kiley, Ben Howard
E76
Jack Hanna, Sharon Jones and the Dap-Kings
E77
Dr. Phil McGraw, Robin Tunney, Diana Krall
E78
Ryan Reynolds, Dierks Bentley
E79
Martin Short, Bettye Lavette
E80
Sienna Miller, Andy Kindler, Bob Mould
E81
Steve Carell, Dr. Cornel West
E82
Courtney Love, Chris Elliott, Rhiannon Giddens
E83
Bill Belichick, Elisabeth Moss, Madisen Ward and the Mama Bear
E84
Tom Hanks, Sturgill Simpson
E85
Bill Hader, Pat McGann, Shakey Graves
E86
Matthew Perry, Adam Scott, Kishi Bashi
E87
Dakota Johnson, David Tochinskiy, Twin Shadow
E88
Will Smith, Grizfolk
E89
Don Cheadle, Ilana Glazer & Abbi Jacobson, Mikky Ekko
E90
Kid Scientists, Sean Hayes, Judah & the Lion
E91
Helen Mirren, the 2015 Daytona 500 winner, Steve Earle
E92
Matthew Broderick, Ellie Kemper, JD McPherson
E93
Julianna Margulies, Eric Ripert, Glass Animals
E94
Kevin Spacey, Lily James, Alabama Shakes
E95
Patricia Arquette, Will Butler
E96
Kelsey Grammer, Stevie Wonder
E97
Lena Dunham, Bobby Cannavale, Andy Kim with Kevin Drew
E98
Kevin Bacon, Jimmie Walker, Airborne Toxic Event
E99
Shailene Woodley, Dr. Cornel West, Matthew E. White
E100
Will Ferrell, Glen Hansard
E101
Norm MacDonald, Theo James
E102
Ben Stiller, Tove Lo
E103
Bill O'Reilly, Aubrey Plaza
E104
James Franco, Jake Johannsen, Action Bronson
E105
Neil Patrick Harris, Charlie Cox, the Suffers
E106
David Duchovny, Josh Gad, Houndmouth
E107
Sen. Al Franken, Billy Eichner, David Sanborn
E108
Kelly Ripa, Aasif Mandvi, Fat White Family
E109
Mike Myers, Nick Griffin, Banks
E110
Sarah Jessica Parker, Julie Chen, Asleep at the Wheel
E111
Billy Crystal, Chris Russo, Chris Stapleton
E112
Michael J. Fox, Iron & Wine, Ben Bridwell
E113
Kevin James, Tom Dreesen, Tracy Chapman
E114
Alec Baldwin, John Mayer
E115
John Travolta, Amy Schumer, the Waterboys
E116
Piedmont Bird Callers, Paul Rudd
E117
Bruce Willis, Dawes
E118
Robert Downey Jr., Chris Russo, Elvis Costello
E119
Jerry Seinfeld, Jason Isbell & Amanda Shires
E120
Scarlett Johansson, John Mellencamp, Todd Rundgren
E121
Michael Keaton, Future Islands
E122
Jack Hanna, John Popper
E123
First Lady Michelle Obama Hootie and the Blowfish
E124
Steve Martin, Emmylou Harris, Rodney Crowell, Amos Lee, Ralph Stanley, Mark O'Connor
E125
President Barack Obama, Will Ferrell, the Avett Brothers, Brandi Carlile
E126
Reese Witherspoon, Nathan Lane, Mumford & Sons
E127
Martin Short, Norah Jones
E128
Tina Fey, First Aid Kit
E129
Ray Romano, Brian Regan, Dave Matthews Band
E130
Howard Stern, Don Rickles
E131
Bill Clinton, Adam Sandler
E132
Julia Roberts, Paul Shaffer, Ryan Adams
E133
Al Pacino, George Clooney, Tom Waits
E134
Oprah Winfrey, Norm Macdonald
E135
Tom Hanks, Eddie Vedder
E136
Bill Murray, Bob Dylan
E137
The Final Late Show with David Letterman
E138
6,028th broadcast
Episode 149
E149
The final episode includes surprises, memorable highlights and the last Top Ten List.