Reese Witherspoon

E1

Reese Witherspoon serves as the celebrity guest announcer during the series premiere of this variety show hosted by Neil Patrick Harris, which features A-list stars, performances, stunts, comedy skits, mini game shows, audience giveaways and hidden camera pranks. Based on the British series "Ant & Dec's Saturday Night Takeaway."

Alec Baldwin

E2

Emmy Award winner Alec Baldwin serves as this week's celebrity guest announcer.

Tyler Perry

E3

Tyler Perry is this week's celebrity guest announcer.

Shaquille O'Neal

E4

Guest announcer Shaq joins Neil for an evening full of fun, games and housewives, with special guests Gloria Estefan, Zachary Levi and Blue Man Group.

Jack Black

E5

Guest announcer Jack Black plus Olympic Gold medalist Apolo Ohno, and journalists Matt Lauer and Savannah Guthrie.

Reba

E6

Guest announcer Reba plus singer OMI, and actors Jesse Tyler Ferguson and Jane Krakowski.

Kelly Ripa

E7

Guest announcer Kelly Ripa plus singer Ray Parker Jr. and journalist Meredith Vieira.

Kelsey Grammer

E8

Guest announcer Kelsey Grammer, the Backstreet Boys perform, plus Olympic gold medalist Apolo Ohno.